Suboxone (buprenorphine & naloxone)
We are very proud to now offer Suboxone & buprenorphine (single drug) for opioid use disorder (OUD) and for chronic pain management. Both of these medications can provide similar pain relief as traditional opioid pain medications, but with far less chance for addiction and reduced overdose potential. These are considered to be "safer" than traditional pain medications.
Buprenorphine for chronic pain?
Buprenorphine may confer some safety advantages when prescribed for chronic pain, since it produces less physical dependence and less opioid-induced hyperalgesia than other opioids, and produces less respiratory depression than other LA opioids.
Advantages of Buprenorphine is a mu-opioid receptor agonist with a high affinity for the receptor but low intrinsic activity, and is an antagonist at the kappa-opioid receptor. It produces little physical dependence, is associated with less opioid-induced hyperalgesia than other opioids, and importantly, produces less respiratory depression than other long-acting opioids. Buprenorphine has a ceiling effect for respiratory depression, but not for analgesia, at clinically meaningful doses. Thus, some clinicians, including some contributors to this topic, feel that it is a safer option than other long-acting opioids.